Hemifacial myohyperplasia sequence

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Información de la publicación
Tipo de publicación



Investigación y estudios

Medio de publicación

Impreso: Revista indexada


This is a report of an additional patient affected by hemifacial myohyperplasia (HMH). We postulate that this condition originates around the fourth gestational week at any step of cranial muscle development from somitomeres to branchial arches, most probably due to prolonged period of proliferation during cranial muscle development, subsequent abnormal contact between cranial neural crest (CNC) cells and cranial myoblasts, and an impaired interaction among CNC cells and cranial myoblasts derivatives. HMH may represent another example of somatic mosaicism and its features can be explained by a combination of morphostatic and morphodynamic mechanisms of pattern formation during development. Here we suggest that HMH is a sequence in which the primary defect is hyperplasia of the facial muscles and the other findings are secondary to this.


Craniofacial Abnormalities/pathology*, Craniofacial Abnormalities/radiography, Facial Asymmetry/pathology

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SNIES Categoría

Health Professions (miscellaneous)

Fecha de publicación 25 de junio de 2010
Fecha de aceptación 28 de febrero de 2010
Medio indexado (nombre)

American Journal of Medical Genetics

Bases de datos donde está referenciada

PMID: 20583183 [PubMed - indexed for MEDLINE]

Información de apoyo a la difusión
Enlaces PUBMED.
Base de datos: U.S. National Library of Medicine

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