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Dengue-yellow fever sera cross-reactivity; challenges for diagnosis


Información de la publicación

Información de la publicación
Tipo de publicación

Científica

Tipología

Investigación y estudios

Medio de publicación

Impreso: Revista indexada

Resumen

Objective: The Flavivirus genera share epitopes inducing cross-reactive antibodies leading to great difficulty in differentially diagnosing flaviviral infections. This work was aimed at evaluating the complexity of dengue and yellow fever serological differential diagnosis. Material and methods: Dengue antibody capture ELISA and a yellow fever neutralisation test were carried out on 13 serum samples obtained from yellow fever patients, 20 acute serum samples from dengue patients and 19 voluntary serum samples pre- and post-vaccination with YF vaccine. Results: Dengue ELISA revealed IgM reactivity in 46,2 % of yellow fever patients and 42 % of vaccinees. Sixteen out of 20 dengue patients (80 %) had high YF virus neutralisation titres. Conclusions: Such very high cross-reactivity data challenged differential laboratory diagnosis of dengue and yellow fever in areas where both flaviviruses co-circulate. New laboratory strategies are thus needed for improving the tests and providing a specific laboratory diagnosis. Cross-reactivity between Flaviviruses represents a great difficulty for epidemiological surveillance and preventing dengue, both of  which demand urgent attention.

Autores

Natalia Houghton-Triviño, Diana Montaña, Jaime E. Castellanos

Registro ISSN

0124-0064

SNIES Área

Immunology and Microbiology

SNIES Categoría

Microbiology

Fecha de publicación 15 de mayo de 2008
Fecha de aceptación 08 de abril de 2008
Medio indexado (nombre)

Pubmed, Scielo

Bases de datos donde está referenciada

Pubmed, Scielo

Información de apoyo a la difusión
Documentos Rev_Salud_Publica_Houghton-Trivino_2008_1_.pdf

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