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Distribution of Porphyromonas gingivalis fimA genotypes in isolates from subgingival plaque and blood sample during bacteremia


Información de la publicación

Información de la publicación
Tipo de publicación

Científica

Tipología

Investigación y estudios

Medio de publicación

Impreso: Revista indexada

Resumen

Introduction. Porphyromonas gingivalis is considered as a major etiological agent in the onset and progression of chronic destructive periodontitis. Porphyromonus gingivalis fimA type has been correlated to the virulence potential of the strain; therefore this gene could be involved in the ability of P. gingivalis to reach blood stream.

Objective. The classifications of P. gingivalis fimA types will be compared in subgingival plaque and blood samples collected after scaling and root root planing of periodontitis patients.

Materials and methods. Fifteen periodontitis patients requiring scaling and root planing were enrolled. P. gingivalis isolates were classed to genotype with fimA type-specific PCR assay. fimA gene was sequenced if the isolate was listed as unclassifiable after PCR technique.

Results. Six patients showed positive P. gingivalis bacteremia. The most frequent fimA was fimA type II, followed by Ib, III and IV. In blood strains, type II was followed by IV, Ib and III.

Conclusion. Type II was the most frequent genotype in blood samples and in subgingival plaque samples. However, no correlation was found between the frequency of any fimA type with SRP induced bacteremia. P. gingivalis fimA type appears to be conserved within individual patients throughout the times of sample collection. fimA gene sequence results were not in agreement with results of fimA genotyping by PCR.

Autores

Paula Juliana Pérez-Chaparro, Gloria Inés Lafaurie, Patrice Gracieux, Vincent Meuric, Zohreh Tamanai-Shacoori, Jaime Eduardo Castellanos, Martine Bonnaure-Mallet

Registro ISSN

ISSN:0120-4157

SNIES Área

Immunology and Microbiology

SNIES Categoría

Microbiology

Fecha de publicación 10 de junio de 2009
Fecha de aceptación 23 de febrero de 2009
Medio indexado (nombre)

Pubmed, Scielo

Bases de datos donde está referenciada

Pubmed, Scielo

Información de apoyo a la difusión
Documentos FimA_Distribution_Colombia_2007.pdf

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