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The rabies virus phosphoprotein synthesis and subcellular localization are modified by nerve growth factor


Información de la publicación

Información de la publicación
Tipo de publicación

Científica

Tipología

Investigación y estudios

Medio de publicación

Impreso: Revista indexada

Resumen

Rabies virus P protein participates as a regulating factor in viral transcription and replication; recent studies found an antitranscriptional and antireplicative effect of nerve growth factor (NGF) and Neurotrophin-3 (NT-3) in infected neuron cultures. We investigated here the specific effect of the neurotrophins on P protein, evaluating its synthesis and subcellular distribution in adult mouse dorsal root ganglia neuron cultures infected and treated with NGF or NT-3. The results showed that NGF, but not NT-3, caused an increase in the quantity of P protein and an accumulation of protein in neuronal bodies, revealing changes in transport to the neuritic processes

Autores

Castaneda NY, Chaparro-Olaya J, Acosta O, Castellanos JE

Registro ISSN

0020-7454

SNIES Área

Biochemistry, Genetics and Molecular Biology

SNIES Categoría

Biochemistry, Genetics and Molecular Biology (miscellaneous)

Fecha de publicación 23 de agosto de 2009
Fecha de aceptación 04 de febrero de 2009
Medio indexado (nombre)

International Journal of Neuroscience

Bases de datos donde está referenciada

MEDLINE

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