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Correlation of th-17 profile with periodontal disease. Corto (Resumen)


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Científica

Tipología

Investigación y estudios

Medio de publicación

Impreso: Revista indexada

Resumen

OBJECTIVES: The products related with Th17 cells include IL-17A, IL-6, IL8, TNF-alpha, IL-1, GM-CSF, MMP among others; these cytokines may have effects especially into monocyte/macrophage cell lines, osteoblast, fibroblast and chondrocytes. The responses associated with Th17 profile go from inflammation to bone loss, which is a characteristics condition of periodontal disease (PD). The aim of this study was to measure and correlate the serum Th17 cytokine profile with clinical parameters of PD. METHODS: Twenty-one patients with PD (nine male and twelve female; mean age 46.7±12.05 years) were selected by AAP criteria, who visited the Periodontal School from Universidad El Bosque. All PD patients had moderate to advanced PD, which was evidenced with radiographic of extensive bone loss. Gingival index, probing depth in affected sites, attachment level and bleeding on probing were evaluated and serum samples were obtained to determine IL-17, TNF-alpha, IL-1alpha, and INF-gamma by means of Cytometric Beads Array (CBA) Flex Set. Clinical parameters were categorized by interquartiles ranges, and its correlation with cytokine levels was determined by means of Spearman's coefficient using SPSS V.14 statistic package for Windows. RESULTS: TNF-alpha and IL-17 serum level correlated with probing depth (r=-0.532,p=0.013) and (r=0.454,p=0.039) respectively. Moreover, IL-17 was correlated with IL-1 alpha (r=0.626,p=0.002) and TNF-alpha (r=0.732,p=0.000), also, IL-1alpha showed correlation with TNF-alpha (r=0.589,p=0.005). CONCLUSION: The underlying mechanisms through which IL-17 influences the development and severity of periodontal disease remain unclear. Periodontal infection could means to chronic periodontal inflammatory condition, and the IL-17 profile might take part in this process, supporting that periodontal inflammation and immune activation entail bone loss with local amplification of Th17 profile.

Autores

C. ROMERO- SANCHEZ,
J. DE AVILA QUIROGA,
M.A. SABOGAL,
G. LAFAURIE

Registro ISSN

1544-0591

SNIES Área

Dentistry

SNIES Categoría

Dentistry (miscellaneous)

Fecha de publicación 17 de mayo de 2011
Fecha de aceptación 01 de diciembre de 2010
Medio indexado (nombre)

Journal of dental research.

Bases de datos donde está referenciada

PubMed

English information
Title

Correlation of th-17 profile with periodontal disease.

Abstract

OBJECTIVES: The products related with Th17 cells include IL-17A, IL-6, IL8, TNF-alpha, IL-1, GM-CSF, MMP among others; these cytokines may have effects especially into monocyte/macrophage cell lines, osteoblast, fibroblast and chondrocytes. The responses associated with Th17 profile go from inflammation to bone loss, which is a characteristics condition of periodontal disease (PD). The aim of this study was to measure and correlate the serum Th17 cytokine profile with clinical parameters of PD. METHODS: Twenty-one patients with PD (nine male and twelve female; mean age 46.7±12.05 years) were selected by AAP criteria, who visited the Periodontal School from Universidad El Bosque. All PD patients had moderate to advanced PD, which was evidenced with radiographic of extensive bone loss. Gingival index, probing depth in affected sites, attachment level and bleeding on probing were evaluated and serum samples were obtained to determine IL-17, TNF-alpha, IL-1alpha, and INF-gamma by means of Cytometric Beads Array (CBA) Flex Set. Clinical parameters were categorized by interquartiles ranges, and its correlation with cytokine levels was determined by means of Spearman's coefficient using SPSS V.14 statistic package for Windows. RESULTS: TNF-alpha and IL-17 serum level correlated with probing depth (r=-0.532,p=0.013) and (r=0.454,p=0.039) respectively. Moreover, IL-17 was correlated with IL-1 alpha (r=0.626,p=0.002) and TNF-alpha (r=0.732,p=0.000), also, IL-1alpha showed correlation with TNF-alpha (r=0.589,p=0.005). CONCLUSION: The underlying mechanisms through which IL-17 influences the development and severity of periodontal disease remain unclear. Periodontal infection could means to chronic periodontal inflammatory condition, and the IL-17 profile might take part in this process, supporting that periodontal inflammation and immune activation entail bone loss with local amplification of Th17 profile.

Keywords

Cytokine, Inflammatory mediators, Periodontal disease and Serum-plasma

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Enlaces 89th General Session and exhibition of th...California
International association for dental research

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