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USA300-related methicillin-resistant Staphylococcus aureus clone is the predominant cause of community and hospital MRSA infections in Colombian children.


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Información de la publicación
Tipo de publicación

Científica

Tipología

Investigación y estudios

Medio de publicación

Impreso: Artículos de investigación científica o tecnológica T1

Resumen

 Objective: Community-genotype Methicillin-Resistant Staphylococcus aureus (CG-MRSA) isolates are known to be more virulent and clinically aggressive among children. The goal of the present study was characterize the molecular epidemiology of MRSA isolates causing infections in Colombian children.

Methods: An observational and prospective study was conducted between April 2009 and June 2011 at 15 hospitals in Bogotá, Colombia. A detailed epidemiological profile was done in 162 infected children with MRSA. Upon the isolates the antimicrobial susceptibility testing, molecular characterization including 21 virulence genes, SCCmec, spa and agr typing, MSLT and PFGE were carried out.

Results: Among all isolates included in the study, 85.8% were obtained from patients that initiated the infectious process in the community, of which, 69.8% occurred in patients without healthcare associated risk factors. The molecular characterization of the isolates showed a high proportion (95.1%) of a community-genotype profile with a high prevalence of SCCmec type IV, PVL-positives and related to CC8. Most CG-MRSA isolates (143, 92.9%) were genetically related to the pandemic clone USA300, differing by the presence of SCCmec IVc and the absence of ACME.

Conclusions: in the world there are recent reports of the increase in the frequency of CG-MRSA infections. Here we showed that almost all MRSA infections in our pediatric population were caused by community genotype isolates, support the success of the CG-MRSA clones.

Autores

Ricaurte Alejandro Marquez-Ortiz, Martha I. Alvarez-Olmos,
Javier Antonio Escobar Perez, Aura Lucia Leal, Betsy Esperanza Castro,Ana Cristina Mariño, Esther Rocio Barrero, Sandra Celina Mujica, Sebastian Gaines, Natasha Vanegas and the Research Group of Pediatric Infectious Diseases

Registro ISSN

12019712

SNIES Área

Medicine

SNIES Categoría

Infectious Diseases

Fecha de publicación 20 de febrero de 2015
Fecha de aceptación 20 de febrero de 2015
Bases de datos donde está referenciada

Scopus

English information
Title

USA300-related methicillin-resistant Staphylococcus aureus clone is the predominant cause of community and hospital MRSA infections in Colombian children.

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