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InterCHANGE: A Latin American Initiative for Head and Neck Cancer research

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5th World Congress of the International Academy of Oral Oncology (IAOO) Sao Paulo Brazil

English information

InterCHANGE: A Latin American Initiative for Head and Neck Cancer research


Introduction: In 2012, almost 42,839 new head and neck cancer (HNC) cases were estimated to occur
in the Latin American (LA) region. Despite the current knowledge on the epidemiology and risk factors
associated to HNC; there are not large scale follow up studies in LA on HNC patients that allow the
simultaneous assessment of the role of HPV, genetics, treatment, tobacco and alcohol use on HNC
incidence, survival and multiple primary tumor development.
Purpose: The InterCHANGE study was designed to better understand the role of risk factors in the
etiology and clinical outcome of HNC in LA.
Method: The study aims to recruit a large series of 2000 cases and 2000 controls from various countries
in LA. Standardized protocols and questionnaires were designed and translated. A centralized online
database and a biorepository were created.
Results:- 8 centers from 4 countries have recruited a total of 1450 cases and 500 controls. A sample
data freeze for cases includes 574 tissue samples, 480 FFPE samples and 1157 base line and 236 follow
up blood samples. The future perspectives embrace:
Description of major risks factors, interactions and differences within the region
Complete genomic profile of cancer subtypes and biological markers of outcome
Identification of second primary tumor incidence and biomarkers of risk prediction
Identification of main gaps and obstacles of early diagnosis and treatment compliance
Conclusions: This consortium represents the larger case control study of HNC in LA to assess the role of
HPV infection, genetic and lifestyle factors in both etiology and survival.

Etiquetado como: head cancer , neck cancer

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