Inicio


Publicación

Myosin B of Plasmodium falciparum (PfMyoB): in silico prediction of its three-dimensional structure and its possible interaction with MTIP


Información de la publicación

Información de la publicación
Tipo de publicación

Científica

Tipología

Investigación y estudios

Medio de publicación

Impreso: Revista indexada

Resumen

The mobility and invasion strategy of Plasmodium falciparum is governed by a protein complex known as the glideosome, which contains an actin-myosin motor. It has been shown that myosin A of the parasite (PfMyoA) is the myosin of the glideosome, and the interaction of PfMyoAwith myosin tail domain interacting protein (MTIP) determines its correct location and its ability to function in the complex.

Because PfMyoA and myosin B of P. falciparum (PfMyoB) share high sequence identity, are both small proteins without a tail domain, belong to the class XIV myosins, and are expressed in late schizonts and merozoites, we suspect that these myosins may have similar or redundant functions.

Therefore, this work examined the structural similarity between PfMyoA and PfMyoB and performed a molecular docking between PfMyoB and MTIP. Three-dimensional (3D) models obtained for PfMyoA and PfMyoB achieved high scores in the structural validation programs used, and their superimposition revealed high structural similarity, supporting the hypothesis of possible similar functions for

these two proteins. The 3D interaction models obtained and energy values found suggested that interaction between PfMyoB and MTIP is possible. Given the apparent abundance of PfMyoA relative to PfMyoB in the parasite, we believe that the interaction between PfMyoB and MTIP would only be detectable in specific cellular environments because under normal circumstances, it would be masked by the interactionbetween PfMyoA and MTIP.

Autores

Paula C. Hernández & Liliana Morales & Isabel C Castellanos & Moisés Wasserman & Jacqueline Chaparro-Olaya

Registro ISSN

1432-1955 (electronic version), 0932-0113 (print version)

DOI Artículo Digital Myosin B of Plasmodium falciparum (PfMyoB... with MTIP
The mobility and invasion strategy of Plasmodium falciparum is governed by a protein complex known as the glideosome, which contains an actin-myosin motor. It has been shown that myosin A of the parasite (PfMyoA) is the myosin of the glideosome, and the i
SNIES Área

Computer Science

SNIES Categoría

Parasitology

Fecha de publicación 07 de marzo de 2017
Fecha de aceptación 21 de febrero de 2017

Información de contacto

Contacto de Publicaciones