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Description of high rates of unapparent and simultaneous multiple dengue virus infection in a Colombian jungle settlement


Información de la publicación

Información de la publicación
Tipo de publicación

Científica

Tipología

Investigación y estudios

Medio de publicación
  • Impreso: Revista de divulgación científica

Resumen

Dengue disease statistics is mainly based on consulting patients with febrile illness, but misdiagnosed and asymptomatic cases are important to measure dengue epidemiology in endemic areas. The main objective of this work was to determine the prevalence of IgM and IgG antibodies or NS1 antigen and viral RNA in a group of healthy volunteers from an isolated village in Colombian Chocó rain forest. It found 51.7% of virologically PCR confirmed asymptomatic cases, despite low IgM seroprevalence. It was confirmed that all four serotypes are in the circulation and in 17.2% of individuals it detected natural coinfections of two or three different serotypes simultaneously. This is the first report in Colombia evaluating viremia in asymptomatic volunteers. These findings pose a big concern about the transmission of dengue virus by asymptomatic individuals because they can spread the virus without take appropriate control measures.

Autores

Castellanos, J.E., Coronel-Ruiz, C., Parra-Alvarez, S., Castilla, M.G., Calvo, E.P.,Arévalo-Herrera, M., Velandia-Romero, M.L.

Registro ISSN

0127-5720

Fecha de publicación 21 de julio de 2017
Fecha de aceptación 02 de enero de 2016
Bases de datos donde está referenciada

The Malaysian Society of Parasitology and Tropical Biomedicine. Tropical Biomedicine

English information
Title

Description of high rates of unapparent and simultaneous multiple dengue virus infection in a Colombian jungle settlement

Abstract

Dengue disease statistics is mainly based on consulting patients with febrile illness, but misdiagnosed and asymptomatic cases are important to measure dengue
epidemiology in endemic areas. The main objective of this work was to determine the prevalence of IgM and IgG antibodies or NS1 antigen and viral RNA in a group of healthy volunteers from an isolated village in Colombian Chocó rain forest. It found 51.7% of virologically
PCR confirmed asymptomatic cases, despite low IgM seroprevalence. It was confirmed that all four serotypes are in the circulation and in 17.2% of individuals it detected natural coinfections
of two or three different serotypes simultaneously. This is the first report in Colombia evaluating viremia in asymptomatic volunteers. These findings pose a big concern about the transmission of dengue virus by asymptomatic individuals because they can spread the virus without take appropriate control measures.

Información de apoyo a la difusión
Documentos Description_of_high_rates_of_unapparent_a...lement.pdf

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